Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases
Identifieur interne : 000462 ( France/Analysis ); précédent : 000461; suivant : 000463Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases
Auteurs : J. Fayette [France] ; E. Martin [France] ; S. Piperno-Neumann [France] ; A. Le Cesne ; C. Robert ; S. Bonvalot ; D. Ranchre [France] ; P. Pouillart [France] ; J. M. Coindre [France] ; J. Y. Blay [France]Source :
- Annals of Oncology [ 0923-7534 ] ; 2007-10-31.
Abstract
Background: Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history. Patients and methods: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004. Survival and prognostic factors for survival were analyzed. Results: Median age was 52 years. Primary sites were the breast (35%), skin (20%) and soft tissues (13%). At initial diagnosis, 31 (19%) had metastases. Surgery was the first treatment in 121 (75%) patients combined with chemotherapy or radiotherapy in 34 and 32, respectively. Ninety (74%) of these 121 patients relapsed, mostly locally (50). With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died. Median survival was 3.4 years [95% confidence interval (CI) 2.45.8], and the 5-year overall survival (OS) rate was 43% (95% CI 3353). In multivariate analysis, liver primary site [relative risk (RR)12.62], performance status (PS) of two or more (RR3.83), presence of metastases at diagnosis (RR2.50), soft tissue tumor (RR0.31) were correlated to OS. PS, liver and soft tissue tumors were identified as independent prognostic factors for progression-free survival. Conclusions: Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site.
Url:
DOI: 10.1093/annonc/mdm381
Affiliations:
- France
- Aquitaine, Auvergne-Rhône-Alpes, Nouvelle-Aquitaine, Rhône-Alpes, Île-de-France
- Bordeaux, Lyon, Paris
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000C49
- to stream Istex, to step Curation: 000C49
- to stream Istex, to step Checkpoint: 001239
- to stream Main, to step Merge: 007546
- to stream Main, to step Curation: 007395
- to stream Main, to step Exploration: 007395
- to stream France, to step Extraction: 000462
Links to Exploration step
ISTEX:1AB7268F9E2D151F17081CF34CA5B12D5F96C14DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases</title><author><name sortKey="Fayette, J" sort="Fayette, J" uniqKey="Fayette J" first="J." last="Fayette">J. Fayette</name></author><author><name sortKey="Martin, E" sort="Martin, E" uniqKey="Martin E" first="E." last="Martin">E. Martin</name></author><author><name sortKey="Piperno Neumann, S" sort="Piperno Neumann, S" uniqKey="Piperno Neumann S" first="S." last="Piperno-Neumann">S. Piperno-Neumann</name></author><author><name sortKey="Le Cesne, A" sort="Le Cesne, A" uniqKey="Le Cesne A" first="A." last="Le Cesne">A. Le Cesne</name></author><author><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C." last="Robert">C. Robert</name></author><author><name sortKey="Bonvalot, S" sort="Bonvalot, S" uniqKey="Bonvalot S" first="S." last="Bonvalot">S. Bonvalot</name></author><author><name sortKey="Ranchre, D" sort="Ranchre, D" uniqKey="Ranchre D" first="D." last="Ranchre">D. Ranchre</name></author><author><name sortKey="Pouillart, P" sort="Pouillart, P" uniqKey="Pouillart P" first="P." last="Pouillart">P. Pouillart</name></author><author><name sortKey="Coindre, J M" sort="Coindre, J M" uniqKey="Coindre J" first="J. M." last="Coindre">J. M. Coindre</name></author><author><name sortKey="Blay, J Y" sort="Blay, J Y" uniqKey="Blay J" first="J. Y." last="Blay">J. Y. Blay</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1AB7268F9E2D151F17081CF34CA5B12D5F96C14D</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1093/annonc/mdm381</idno><idno type="url">https://api.istex.fr/document/1AB7268F9E2D151F17081CF34CA5B12D5F96C14D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C49</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C49</idno><idno type="wicri:Area/Istex/Curation">000C49</idno><idno type="wicri:Area/Istex/Checkpoint">001239</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001239</idno><idno type="wicri:doubleKey">0923-7534:2007:Fayette J:angiosarcomas:a:heterogeneous</idno><idno type="wicri:Area/Main/Merge">007546</idno><idno type="wicri:Area/Main/Curation">007395</idno><idno type="wicri:Area/Main/Exploration">007395</idno><idno type="wicri:Area/France/Extraction">000462</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases</title><author><name sortKey="Fayette, J" sort="Fayette, J" uniqKey="Fayette J" first="J." last="Fayette">J. Fayette</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><wicri:orgArea>Hospices Civils de Lyon, Universit Lyon1, Hpital Edouard. Herriot, Oncologie Mdicale, Pavillon E</wicri:orgArea></affiliation><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><wicri:orgArea>Unit Institut National de la Sant et de la Recherche Mdicale 590, Universit Lyon 1, Centre Lon Brard</wicri:orgArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Martin, E" sort="Martin, E" uniqKey="Martin E" first="E." last="Martin">E. Martin</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><wicri:orgArea>Sant Publique, Centre Lon Brard</wicri:orgArea></affiliation></author><author><name sortKey="Piperno Neumann, S" sort="Piperno Neumann, S" uniqKey="Piperno Neumann S" first="S." last="Piperno-Neumann">S. Piperno-Neumann</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Oncologic Mdicale Institut Curie</wicri:orgArea></affiliation></author><author><name sortKey="Le Cesne, A" sort="Le Cesne, A" uniqKey="Le Cesne A" first="A." last="Le Cesne">A. Le Cesne</name><affiliation><wicri:noCountry code="subField">Villejuif</wicri:noCountry></affiliation></author><author><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C." last="Robert">C. Robert</name><affiliation><wicri:noCountry code="subField">Villejuif</wicri:noCountry></affiliation></author><author><name sortKey="Bonvalot, S" sort="Bonvalot, S" uniqKey="Bonvalot S" first="S." last="Bonvalot">S. Bonvalot</name><affiliation><wicri:noCountry code="no comma">Service de Chirurgie</wicri:noCountry></affiliation></author><author><name sortKey="Ranchre, D" sort="Ranchre, D" uniqKey="Ranchre D" first="D." last="Ranchre">D. Ranchre</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Service d'anatomo-pathologie, Institut Curie</wicri:orgArea></affiliation></author><author><name sortKey="Pouillart, P" sort="Pouillart, P" uniqKey="Pouillart P" first="P." last="Pouillart">P. Pouillart</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Oncologic Mdicale Institut Curie</wicri:orgArea></affiliation></author><author><name sortKey="Coindre, J M" sort="Coindre, J M" uniqKey="Coindre J" first="J. M." last="Coindre">J. M. Coindre</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anatomo-Pathologie, Institut Bergoni, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Blay, J Y" sort="Blay, J Y" uniqKey="Blay J" first="J. Y." last="Blay">J. Y. Blay</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><wicri:orgArea>Hospices Civils de Lyon, Universit Lyon1, Hpital Edouard. Herriot, Oncologie Mdicale, Pavillon E</wicri:orgArea></affiliation><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><wicri:orgArea>Unit Institut National de la Sant et de la Recherche Mdicale 590, Universit Lyon 1, Centre Lon Brard</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2007-10-31">2007-10-31</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2030">2030</biblScope><biblScope unit="page" to="2036">2036</biblScope></imprint><idno type="ISSN">0923-7534</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0923-7534</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history. Patients and methods: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004. Survival and prognostic factors for survival were analyzed. Results: Median age was 52 years. Primary sites were the breast (35%), skin (20%) and soft tissues (13%). At initial diagnosis, 31 (19%) had metastases. Surgery was the first treatment in 121 (75%) patients combined with chemotherapy or radiotherapy in 34 and 32, respectively. Ninety (74%) of these 121 patients relapsed, mostly locally (50). With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died. Median survival was 3.4 years [95% confidence interval (CI) 2.45.8], and the 5-year overall survival (OS) rate was 43% (95% CI 3353). In multivariate analysis, liver primary site [relative risk (RR)12.62], performance status (PS) of two or more (RR3.83), presence of metastases at diagnosis (RR2.50), soft tissue tumor (RR0.31) were correlated to OS. PS, liver and soft tissue tumors were identified as independent prognostic factors for progression-free survival. Conclusions: Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Aquitaine</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Bordeaux</li><li>Lyon</li><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Bonvalot, S" sort="Bonvalot, S" uniqKey="Bonvalot S" first="S." last="Bonvalot">S. Bonvalot</name><name sortKey="Le Cesne, A" sort="Le Cesne, A" uniqKey="Le Cesne A" first="A." last="Le Cesne">A. Le Cesne</name><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C." last="Robert">C. Robert</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Fayette, J" sort="Fayette, J" uniqKey="Fayette J" first="J." last="Fayette">J. Fayette</name></region><name sortKey="Blay, J Y" sort="Blay, J Y" uniqKey="Blay J" first="J. Y." last="Blay">J. Y. Blay</name><name sortKey="Blay, J Y" sort="Blay, J Y" uniqKey="Blay J" first="J. Y." last="Blay">J. Y. Blay</name><name sortKey="Coindre, J M" sort="Coindre, J M" uniqKey="Coindre J" first="J. M." last="Coindre">J. M. Coindre</name><name sortKey="Fayette, J" sort="Fayette, J" uniqKey="Fayette J" first="J." last="Fayette">J. Fayette</name><name sortKey="Fayette, J" sort="Fayette, J" uniqKey="Fayette J" first="J." last="Fayette">J. Fayette</name><name sortKey="Martin, E" sort="Martin, E" uniqKey="Martin E" first="E." last="Martin">E. Martin</name><name sortKey="Piperno Neumann, S" sort="Piperno Neumann, S" uniqKey="Piperno Neumann S" first="S." last="Piperno-Neumann">S. Piperno-Neumann</name><name sortKey="Pouillart, P" sort="Pouillart, P" uniqKey="Pouillart P" first="P." last="Pouillart">P. Pouillart</name><name sortKey="Ranchre, D" sort="Ranchre, D" uniqKey="Ranchre D" first="D." last="Ranchre">D. Ranchre</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000462 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000462 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:1AB7268F9E2D151F17081CF34CA5B12D5F96C14D
|texte= Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases
}}
| This area was generated with Dilib version V0.6.31. |  |